does apolipoprotein a-ii polymorphism interact with the association of obesity and serum inflammatory biomarkers in type 2 diabetes patients?

b a ckground: the objective was to investigate the relationship between serum interleukin-18 (il-18), pentraxin 3 (ptx3), and high-sensitivity c-reactive protein (hs-crp) levels with body mass index (bmi) and abdominal obesity and also the interaction between genetic variants of apolipoprotein a-ii (apo a-ii) and obesity on the levels of these factors in type 2 diabetes patients (t2d). m ethods :  a  comparative  cross-sectional study  was  conducted  in  21  diabetes centers in tehran. totally, 180 (35-65 years) t2d patients were divided into two groups of 90 obese (bmi ≥ 30) and 90 non-obese (bmi < 30), according to the bmi with equal numbers of each genotype of apo a-ii: 30 tt, 30 cc, and 30 tc. serum il-18, ptx3, and hs-crp concentrations were compared between two obese  and  non-obese  groups  and  between  subjects  with  and  without  central obesity. to investigate the interaction of apo a-ii genetic variants and bmi with inflammatory factors, general linear model was used. results : after adjusting data with confounding factors, the mean of serum ptx3 was significantly lower (p < 0.050) in the obese diabetes than non-obese diabetes subjects. moreover, obese diabetes had higher serum hs-crp level that on obese subjects (p < 0.010). no significant interaction between apo a-ii 265 t > c polymorphism and bmi on inflammatory biomarkers was observed. conclusion : there was a significant difference in inflammatory markers (ptx3 and hs-crp concentration) between obese and non-obese diabetes. in addition, there was no interaction of apo a-ii 265 t > c genotypes and bmi on inflammatory markers. weight control may be recommended to modulate inflammation and its complications in obese patients.